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KMID : 0385019970130020131
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Korean Journal of Laboratory Animal Science
1997 Volume.13 No. 2 p.131 ~ p.134
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Localization and Induction of Cytochrome P4502E1 in Disease Status of Mice
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박상준/Park, Sang joon
이철호/현병화/최양규/정규식/윤원기/민병길/Lee, Chul Ho/Hyun, Byung Hwa/Choi, Yang Kyu/Jeong, Kyu Shik/Yoon, Won Kee/Mheen, Byoung Gil
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Abstract
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The regional expressions of cytochrome P4502E1(CYP4502E1) on MRL/MpOlaHsd-lpr(MRL), NOD/ShiKist (NOD), and FGS/NgaKiet (FGS) male mice was studied by immunohistoehemistry. Three strains were used to investigate specific distribution of the enzyme in differential endogenous disease statue. Hepatic cytochrome P4602E1 immunereactivity was significantly increased in disease status, mainly is the perlcentral area of expression of MRL, NOD and FGS male mice. These data demonstrate that the selectivity of protein expression may be of significance in assessing cell specific toxicities not only dependent on exogenous factors in induced status, but also endogenous factors like acute or chronic hepatitis, genetic diabetes, and renalpathy.
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KEYWORD
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